Persistent adrenal insufficiency secondary to low-dose ketoconazole therapy
| Autor: | Murphy Fy, Bussell Kl, Nicks Sa, John K. Jenkins, Timothy R. Best, David L. Vesely |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
medicine.medical_specialty
Endocrine testing Lung Diseases Fungal business.industry Low dose General Medicine Middle Aged medicine.disease Gastroenterology Blastomycosis Ketoconazole Endocrinology Internal medicine Toxicity Adrenal insufficiency medicine Humans Female business Glucocorticoids Adrenocortical Insufficiency Adrenal Insufficiency medicine.drug |
| Zdroj: | The American Journal of Medicine. 82:676-680 |
| ISSN: | 0002-9343 |
| DOI: | 10.1016/0002-9343(87)90123-9 |
| Popis: | Persistent adrenal insufficiency secondary to ketoconazole therapy has not previously been documented. A case of adrenocortical insufficiency secondary to low-dose (400 mg per day) ketoconazole therapy for blastomycosis is described. Symptomatic adrenal insufficiency was documented on endocrine testing, required physiologic replacement doses of glucocorticoids, and has not been reversible in two years of follow-up. Thus, adrenal insufficiency may be caused by low-dose ketoconazole therapy, and such adrenal insufficiency may have a prolonged course. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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