Soluble CD163: a biomarker linking macrophages and insulin resistance
| Autor: | Bente Klarlund Pedersen, Lars Peter Sørensen, Bo Martin Bibby, Christian P. Fischer, Holger Jon Møller, Anders R. Nielsen, Tina Parkner, Søren Nielsen |
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| Rok vydání: | 2012 |
| Předmět: |
Adult
Male medicine.medical_specialty Endocrinology Diabetes and Metabolism medicine.medical_treatment Antigens Differentiation Myelomonocytic Receptors Cell Surface Type 2 diabetes Biology Impaired glucose tolerance Insulin resistance Antigens CD Internal medicine Diabetes mellitus Glucose Intolerance Internal Medicine medicine Humans Aged Univariate analysis Glucose tolerance test medicine.diagnostic_test Interleukin-6 Tumor Necrosis Factor-alpha Macrophages Insulin nutritional and metabolic diseases Glucose Tolerance Test Middle Aged medicine.disease Cross-Sectional Studies Endocrinology Diabetes Mellitus Type 2 Case-Control Studies Female Insulin Resistance Metabolic syndrome |
| Zdroj: | Parkner, T, Sørensen, L P, Nielsen, A R, Fischer, C P, Bibby, B M, Nielsen, S, Pedersen, B K & Møller, H J 2012, ' Soluble CD163: a biomarker linking macrophages and insulin resistance ', Diabetologia . https://doi.org/10.1007/s00125-012-2533-1 |
| ISSN: | 1432-0428 0012-186X |
| DOI: | 10.1007/s00125-012-2533-1 |
| Popis: | Soluble CD163 (sCD163) was recently identified as a strong risk marker for developing type 2 diabetes. We hypothesised that sCD163 independently associates with insulin resistance. This cross-sectional study includes 234 participants: 96 with type 2 diabetes, 34 with impaired glucose tolerance (IGT) and 104 with normal glucose tolerance (NGT), matched for sex and BMI. Glucose-lowering medication was paused for 1 week before plasma samples were obtained for determination of sCD163 and other inflammatory and metabolic variables. Insulin resistance was estimated by homeostasis model assessment of insulin resistance (HOMA-IR). Concentrations of sCD163 were 1.95 mg/l (0.63–6.97) in individuals with type 2 diabetes, 1.64 mg/l (0.58–4.19) in those with IGT, and 1.48 mg/l (0.48–4.11) (median [range]) in those with NGT (p |
| Databáze: | OpenAIRE |
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