How intestinal epithelial cells tolerise dendritic cells and its relevance to inflammatory bowel disease
| Autor: | S Ghosh, Matthew Shale |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Antigen presentation
Inflammation Immune tolerance Mice Immune system Antigen Immune Tolerance Medicine Animals Humans Mice Knockout Antigen Presentation business.industry Gastroenterology Epithelial Cells Dendritic cell Bacterial Infections Dendritic Cells Inflammatory Bowel Diseases Intestinal epithelium Epithelium Cell biology Intestines medicine.anatomical_structure Immunology Models Animal medicine.symptom business |
| Zdroj: | Gut. 58(9) |
| ISSN: | 1468-3288 |
| Popis: | Intestinal epithelial layer is an important barrier against antigen invasion. In addition to its barrier function, the immunomodulatory role of intestinal epithelium is attracting considerable attention. The intestinal epithelium may influence underlying immune cells including dendritic cells and lymphocytes and promote tolerogenic and regulatory responses in health. Breakdown of such regulatory influences may result in uncontrolled inflammation and tissue damage. The molecules mediating such regulation derived from intestinal epithelium and their interaction with immune cells may provide novel targets and therapeutic molecules that have translational potential in intestinal inflammation. Understanding the cross-talk between intestinal epithelium and immune cells has progressed from in vitro co-culture models to epithelial cell conditional knockout models. |
| Databáze: | OpenAIRE |
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