A brainstem-central amygdala circuit underlies defensive responses to learned threats
| Autor: | Robert M. Sears, Gary Aston-Jones, Walter T. Piper, Longnian Lin, Elena M. Vazey, Yiran Gu, Lauren A. Branigan, Joseph E. LeDoux |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Male Cell Conditioning Classical Amygdala Article Rats Sprague-Dawley 03 medical and health sciences Cellular and Molecular Neuroscience Norepinephrine 0302 clinical medicine Brain Nucleus medicine Avoidance Learning Animals Psychology Molecular Biology Neurons Basolateral Nuclear Complex Central nucleus of the amygdala Central Amygdaloid Nucleus Fear Rats Psychiatry and Mental health 030104 developmental biology medicine.anatomical_structure Lateral nucleus Locus coeruleus Locus Coeruleus Brainstem Neuroscience 030217 neurology & neurosurgery medicine.drug Brain Stem |
| Zdroj: | Molecular Psychiatry |
| ISSN: | 1476-5578 |
| Popis: | Norepinephrine (NE) plays a central role in the acquisition of aversive learning via actions in the lateral nucleus of the amygdala (LA) [1, 2]. However, the function of NE in expression of aversively-conditioned responses has not been established. Given the role of the central nucleus of the amygdala (CeA) in the expression of such behaviors [3–5], and the presence of NE axons projections in this brain nucleus [6], we assessed the effects of NE activity in the CeA on behavioral expression using receptor-specific pharmacology and cell- and projection-specific chemogenetic manipulations. We found that inhibition and activation of locus coeruleus (LC) neurons decreases and increases freezing to aversively conditioned cues, respectively. We then show that locally inhibiting or activating LC terminals in CeA is sufficient to achieve this bidirectional modulation of defensive reactions. These findings support the hypothesis that LC projections to CeA are critical for the expression of defensive responses elicited by conditioned threats. |
| Databáze: | OpenAIRE |
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