Lipid rafts and the initiation of T cell receptor signaling
| Autor: | Hai-Tao He, Didier Marguet, Annemarie C. Lellouch |
|---|---|
| Přispěvatelé: | Centre d'Immunologie de Marseille - Luminy (CIML), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Aix Marseille Université (AMU), Aix Marseille Université (AMU)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2005 |
| Předmět: |
Antigens
Differentiation T-Lymphocyte MESH: Signal Transduction Liquid ordered phase T cell Immunology Receptors Antigen T-Cell MESH: Membrane Microdomains chemical and pharmacologic phenomena Biology 03 medical and health sciences Membrane Microdomains MESH: Cholesterol 0302 clinical medicine medicine Humans Immunology and Allergy Receptor Lipid raft 030304 developmental biology 0303 health sciences MESH: Humans TCR signalosome T-cell receptor MESH: Receptors Antigen T-Cell hemic and immune systems Cell biology Cholesterol Signalling medicine.anatomical_structure MESH: Antigens Differentiation T-Lymphocyte [SDV.IMM]Life Sciences [q-bio]/Immunology lipids (amino acids peptides and proteins) Signal transduction Signal Transduction 030215 immunology |
| Zdroj: | Seminars in Immunology Seminars in Immunology, Elsevier, 2005, 17 (1), pp.23-33. ⟨10.1016/j.smim.2004.09.001⟩ Seminars in Immunology, 2005, 17 (1), pp.23-33. ⟨10.1016/j.smim.2004.09.001⟩ |
| ISSN: | 1044-5323 1096-3618 |
| Popis: | The role of lipid rafts in T cell signalling has recently been extensively studied and hotly debated. In this review we wish to present recent advances in the study of lipid rafts with regards to the initiation of TCR signal transduction. We also wish to clarify some common misconceptions regarding certain models and experimental methods reported in the literature. Based on the relevant data supporting the functional importance of lipid rafts in early TCR mediated signalling events, we propose a model for TCR signal initiation involving a "TCR signalosome" organized in a specific raft subset, which is highly dynamic and evolving upon TCR activation. |
| Databáze: | OpenAIRE |
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