Cardiac sparing characteristics of internal mammary chain radiotherapy using deep inspiration breath hold for left-sided breast cancer

Autor: L. Christine Fang, Myra Lavilla, Janice N. Kim, Macklin H. Nguyen
Rok vydání: 2017
Předmět:
lcsh:Medical physics. Medical radiology. Nuclear medicine
Adult
Organs at Risk
medicine.medical_specialty
Nodal irradiation
lcsh:R895-920
medicine.medical_treatment
Internal mammary nodes
Radiosurgery
lcsh:RC254-282
Left sided
Breath Holding
03 medical and health sciences
0302 clinical medicine
Breast cancer
Dosimetry
Regional nodal irradiation
Unilateral Breast Neoplasms
Medicine
Humans
Radiology
Nuclear Medicine and imaging
030212 general & internal medicine
Deep inspiration breath-hold
Aged
Cardiac sparing
Coronary event
Deep inspiration breath hold
business.industry
Research
Heart
Radiotherapy Dosage
Middle Aged
lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens
medicine.disease
Survival Analysis
Cardiotoxicity
Radiation therapy
Treatment Outcome
Oncology
030220 oncology & carcinogenesis
Lymph Node Excision
Female
Radiology
business
Zdroj: Radiation Oncology (London, England)
Radiation Oncology, Vol 13, Iss 1, Pp 1-8 (2018)
ISSN: 1748-717X
Popis: Background While breast radiotherapy typically includes regional nodal basins, the treatment of the internal mammary nodes (IMN) has been controversial due to concern for long-term cardiac toxicity. For high risk patients where IMN treatment is warranted, there is limited data with regards to the degree of heart sparing conferred by modern techniques. In this study, we sought to analyze the specific heart sparing metrics conferred by deep inspiration breath hold (DIBH) in the setting of IMN irradiation. Methods From 2012 to 2015, 168 consecutive patients were treated with adjuvant left-sided radiotherapy using DIBH. Retrospective review identified 49 patients who received nodal irradiation, either to a supraclavicular field (SCF) and IMN (16), or to the SCF alone (33). Cardiac mean dose and dose volumes were calculated from free breathing (FB) and DIBH treatment plans, and compared by Wilcoxon signed-rank and Mann–Whitney U tests. Results DIBH achieved significant reductions in mean heart dose (p
Databáze: OpenAIRE
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