Antipsychotics and cardiovascular risk: A case/non-case study

Autor: Susana Pérez García, Luis H. Martín Arias, Pilar García Ortega, Rosario Sanz Fadrique, María Sáinz Gil, Carlos Treceño Lobato
Rok vydání: 2018
Předmět:
Male
Databases
Factual
medicine.medical_treatment
Myocardial Ischemia
Dietary Exposure
Death
Sudden
Pharmacovigilance
0302 clinical medicine
Risk Factors
Torsades de Pointes
Odds Ratio
030212 general & internal medicine
Child
Aged
80 and over
education.field_of_study
Mental Disorders
Middle Aged
Stroke
Psychiatry and Mental health
Breast Feeding
Drug class
Cardiovascular Diseases
Child
Preschool
Female
Antipsychotic Agents
Adult
medicine.medical_specialty
Adolescent
Population
Sudden death
Young Adult
03 medical and health sciences
Internal medicine
medicine
Adverse Drug Reaction Reporting Systems
Humans
Adverse effect
Antipsychotic
education
Biological Psychiatry
Aged
business.industry
Infant
Arrhythmias
Cardiac
Odds ratio
Confidence interval
Spain
Case-Control Studies
business
030217 neurology & neurosurgery
Zdroj: Psychiatry Research. 270:341-347
ISSN: 0165-1781
DOI: 10.1016/j.psychres.2018.09.014
Popis: Severe mental disorders have been reported to be associated with an increased cardiovascular risk. To measure the potential risk excess as compared, not with the baseline cardiovascular risk for the general population, but with the cardiovascular risk associated with drug iatrogenia. 197 reported cases of cardiovascular adverse reaction to antipsychotic drugs as compared to the reported cases of this type of adverse reactions to drugs other than antipsychotics entered in the Spanish Pharmacovigilance System database (FEDRA) (1995–2018) in an observational case/non-case study. Risk estimates of association were reporting odds ratio (ROR), and, chi-square test (χ2). Overall disproportionality for the whole drug class was found [ROR 2.3 (95% CI 2.0–2.7)], χ2 = 127.07]. When the two types of antipsychotics (typical and atypical) were analysed separately, we also found statistically significant disproportionality, and this disproportionality is similar between both groups, with disproportionality measures around 2.30, with the confidence intervals not including the 1. The disproportionality observed suggests a risk excess that might be greater than expected, which holds particularly true for torsade de pointes, sudden death and cardiac arrhythmias in patients treated with any of the two types of antipsychotics. There was no significant risk for ischaemic heart disease.
Databáze: OpenAIRE
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