Kingella kingae as the Main Cause of Septic Arthritis
| Autor: | Sara Zarzoso-Fernández, Mercedes Marín, María Del Carmen Suárez-Arrabal, Jose Luis González-López, María Del Mar Santos-Sebastián, Javier Narbona-Cárceles, Ángel J Villa-García, Azucena García-Martín, María Belén Hernández-Rupérez, Felipe González-Martínez, Marisa Navarro-Gómez, Jesús Saavedra-Lozano, Teresa Hernández-Sampelayo, Paloma Cervera-Bravo |
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| Rok vydání: | 2018 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) medicine.medical_specialty Anemia Neisseriaceae Infections 030106 microbiology Arthritis Kingella kingae medicine.disease_cause Polymerase Chain Reaction 03 medical and health sciences 0302 clinical medicine RNA Ribosomal 16S 030225 pediatrics Internal medicine Epidemiology Humans Medicine Retrospective Studies Arthritis Infectious biology business.industry Osteomyelitis Infant medicine.disease biology.organism_classification Infectious Diseases Spain Staphylococcus aureus Child Preschool Pediatrics Perinatology and Child Health Etiology Female Septic arthritis business |
| Zdroj: | Pediatric Infectious Disease Journal. 37:1211-1216 |
| ISSN: | 0891-3668 |
| DOI: | 10.1097/inf.0000000000002068 |
| Popis: | BACKGROUND Kingella kingae is an emergent pathogen causing septic arthritis (SA) in children.The objective of this study was to analyze the etiology of SA in children before and after the implementation of universal 16S rRNA gene polymerase chain reaction and sequencing (16SPCR) in synovial fluid. METHODS Children ≤14 years with acute SA from a Madrid cohort (2002-2013) were reviewed. Differences in etiology were analyzed before (period 1) and after (period 2) the implementation of bacterial 16SPCR in 2009. A comparison in epidemiology, clinical syndromes, therapy and outcome between infections caused by K. kingae and other bacteria was performed. RESULTS Bacteria were detected from 40/81 (49.4%) children, with a higher proportion of diagnosis after 16SPCR establishment (period 2, 63% vs. period 1, 31.4%; P = 0.005). The main etiologies were Staphylococcus aureus (37.5%) and K. kingae (35%), although K. kingae was the most common microorganism in P2 (48.3%). Children with K. kingae SA were less likely to be younger than 3 months (0 vs. 42.3%; P < 0.001), had less anemia (21.4 vs. 50%; P = 0.010), lower C-reactive protein (3.8 vs. 8.9 mg/dL; P = 0.039), less associated osteomyelitis (0 vs. 26.9%; P = 0.033), shorter intravenous therapy (6 vs. 15 days; P < 0.001), and had a nonsignificant lower rate of sequelae (0 vs. 30%; P = 0.15) than children with SA caused by other bacteria. However, they tended to have higher rate of fever (86 vs. 57%; P = 0.083). CONCLUSIONS K. kingae was frequently recovered in children with SA after the implementation of bacterial 16SPCR, producing a milder clinical syndrome and better outcome. Therefore, the use of molecular techniques may be important for the management of these children. |
| Databáze: | OpenAIRE |
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