Serotonin blocks vasopressin-facilitated offensive aggression: interactions within the ventrolateral hypothalamus of golden hamsters
| Autor: | Craig F. Ferris, Karim M. Mansour, Yvin Delville |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Male
endocrine system medicine.medical_specialty Vasopressin Receptors Vasopressin Serotonin Microinjections Vasopressins Serotonin reuptake inhibitor Hypothalamus Middle Experimental and Cognitive Psychology Rats Sprague-Dawley Stereotaxic Techniques Behavioral Neuroscience Internal medicine Cricetinae Fluoxetine medicine Animals Testosterone 5-HT receptor Mesocricetus Vasopressin receptor binding Rats Serotonin Receptor Agonists Aggression Endocrinology Hypothalamus Autoradiography 5-HT1 receptor Psychology hormones hormone substitutes and hormone antagonists Selective Serotonin Reuptake Inhibitors medicine.drug |
| Zdroj: | Physiologybehavior. 59(4-5) |
| ISSN: | 0031-9384 |
| Popis: | In golden hamsters, vasopressin (AVP) microinjected within the ventrolateral hypothalamus (VLH) facilitates offensive aggression. As serotonin is known to inhibit offensive aggression, we decided to test whether AVP-facilitated behavior is also inhibited by serotonin treatment. Testosterone-treated male golden hamsters received IP injections of fluoxetine, a serotonin reuptake inhibitor, or vehicle 1 h prior to AVP microinjections within the VLH. The animals were tested for offensive aggression in a resident-intruder model after the microinjections, and the results were compared between groups. Pretreatment with fluoxetine inhibited AVP-facilitated offensive aggression. Only one out of nine fluoxetine-treated animals attacked and bit the intruders, compared to six out of seven vehicle-treated animals. Furthermore, we also confirmed by in vitro autoradiography that the VLH contains vasopressin V(1) and serotonin 5-HT1B receptors. Therefore, it is possible that serotonin may inhibit AVP-facilitated offensive aggression by acting directly at the level of the VLH as well as at other sites. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect