Anti Müllerian Hormone (AMH) level and expression in mural and cumulus cells in relation to age
| Autor: | Raoul Orvieto, Rina Hemi, Alon Kedem, Jigal Haas, Gil M. Yerushalmi, Jehoshua Dor, Ettie Maman, Yuval Yung, Mirit Hanochi, Ariel Hourvitz |
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| Rok vydání: | 2014 |
| Předmět: |
Adult
Anti-Mullerian Hormone medicine.medical_specialty endocrine system Aging medicine.medical_treatment Oocyte Retrieval Fertilization in Vitro Andrology Young Adult Internal medicine Follicular phase Obstetrics and Gynaecology medicine Humans Prospective Studies Young adult Prospective cohort study In vitro fertilisation Cumulus Cells Granulosa Cells biology urogenital system Research Age Factors Obstetrics and Gynecology Anti-Müllerian hormone Middle Aged Oocyte Follicular fluid female genital diseases and pregnancy complications Follicular Fluid Endocrinology medicine.anatomical_structure Oncology biology.protein Female Folliculogenesis hormones hormone substitutes and hormone antagonists |
| Zdroj: | Journal of Ovarian Research |
| ISSN: | 1757-2215 |
| Popis: | Background Serum AMH is declining with age and is highly associated with ovarian follicular reserve and disordered folliculogenesis. However, the precise role of AMH in the process of human follicular aging has still to be determined. Aim This study investigates AMH level in the follicular fluid (FF) and mRNA expression pattern in cumulus and mural granulosa cells of human ovarian follicles in relation to age. Methods We conducted a prospective study. Sixty-eight women undergoing In vitro fertilization (IVF) treatment were enrolled in the study. We obtained FF, mural and cumulus granulosa cells from large preovulatory follicles (17-20 mm) of 21–35 years old women (n = 40) and 40–45 years old women (n = 28) during oocyte pickup. Results Higher level of AMH mRNA expression in cumulus cells was observed in the older age group compared to the younger (P |
| Databáze: | OpenAIRE |
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