Hepatic involvement by T-cell neoplasms: a clinicopathologic study of 40 cases
Autor: | Peng Li, Zenggang Pan, Jiehao Zhou, Yulei Shen, Xiaoyan Liao, Dongwei Zhang, Andrew G. Evans, Philippa Li |
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Rok vydání: | 2020 |
Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Databases Factual Biopsy T-Lymphocytes T cell Lymphoma T-Cell medicine.disease_cause Risk Assessment Gastroenterology Immunophenotyping Pathology and Forensic Medicine Young Adult 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine Biomarkers Tumor medicine Humans Neoplasm Child Aged Bone Marrow Transplantation Retrospective Studies business.industry Mortality rate Liver Neoplasms Not Otherwise Specified Age Factors Lymphoma T-Cell Peripheral Middle Aged Prognosis medicine.disease Immunohistochemistry Epstein–Barr virus United States Liver Transplantation Lymphoma Hepatic Involvement 030104 developmental biology medicine.anatomical_structure Child Preschool 030220 oncology & carcinogenesis Female business |
Zdroj: | Human Pathology. 106:1-12 |
ISSN: | 0046-8177 |
Popis: | Hepatic involvement by a T-cell neoplasm is rare and often challenging to diagnose in liver biopsies. We collected 40 cases of T-cell neoplasms diagnosed in the liver from five large academic institutions to assess the clinicopathologic features. The patients included 11 women and 29 men, with a median age of 54 (range: 2-75) years and a high mortality rate (31/37, 83.8%). Fourteen (35%) patients were diagnosed with hepatosplenic T-cell lymphoma (HSTCL), 13 (32.5%) peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 (32.5%) other types of T-cell neoplasms. Patients with HSTCL were much younger and had worse survival than PTCL-NOS and other T-cell neoplasms (P 0.05). On imaging studies, 20 cases (50%) showed abnormalities, including 10 with mass lesions that correlated with normal or cholestatic pattern enzyme elevation. Histomorphological analysis revealed four main patterns; with the exception of mass forming lesions (pattern 4; n = 8), cases with sinusoidal predominant (pattern 1; n = 12), portal predominant with sinusoidal infiltrates (pattern 2; n = 13) or lobular aggregates (pattern 3; n = 5) demonstrated small to medium lymphocytes resembling a reactive/inflammatory process. In addition, we described two cases of T-cell large granular lymphocytic leukemia that mimicked HSTCL, and a case of aggressive post-transplant lymphoproliferative disorder that developed after chronic Epstein-barr virus (EBV) infection, suggesting the importance of EBV testing in some lymphoma cases. As the largest cohort of T-cell neoplasms in liver, our study provides critical data on disease frequency, distribution, and clinicopathologic features that are essential for accurate diagnosis. |
Databáze: | OpenAIRE |
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