Hepatic involvement by T-cell neoplasms: a clinicopathologic study of 40 cases

Autor: Peng Li, Zenggang Pan, Jiehao Zhou, Yulei Shen, Xiaoyan Liao, Dongwei Zhang, Andrew G. Evans, Philippa Li
Rok vydání: 2020
Předmět:
Adult
Male
0301 basic medicine
medicine.medical_specialty
Databases
Factual
Biopsy
T-Lymphocytes
T cell
Lymphoma
T-Cell
medicine.disease_cause
Risk Assessment
Gastroenterology
Immunophenotyping
Pathology and Forensic Medicine
Young Adult
03 medical and health sciences
0302 clinical medicine
Risk Factors
Internal medicine
Biomarkers
Tumor
medicine
Humans
Neoplasm
Child
Aged
Bone Marrow Transplantation
Retrospective Studies
business.industry
Mortality rate
Liver Neoplasms
Not Otherwise Specified
Age Factors
Lymphoma
T-Cell
Peripheral
Middle Aged
Prognosis
medicine.disease
Immunohistochemistry
Epstein–Barr virus
United States
Liver Transplantation
Lymphoma
Hepatic Involvement
030104 developmental biology
medicine.anatomical_structure
Child
Preschool
030220 oncology & carcinogenesis
Female
business
Zdroj: Human Pathology. 106:1-12
ISSN: 0046-8177
Popis: Hepatic involvement by a T-cell neoplasm is rare and often challenging to diagnose in liver biopsies. We collected 40 cases of T-cell neoplasms diagnosed in the liver from five large academic institutions to assess the clinicopathologic features. The patients included 11 women and 29 men, with a median age of 54 (range: 2-75) years and a high mortality rate (31/37, 83.8%). Fourteen (35%) patients were diagnosed with hepatosplenic T-cell lymphoma (HSTCL), 13 (32.5%) peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS), and 13 (32.5%) other types of T-cell neoplasms. Patients with HSTCL were much younger and had worse survival than PTCL-NOS and other T-cell neoplasms (P 0.05). On imaging studies, 20 cases (50%) showed abnormalities, including 10 with mass lesions that correlated with normal or cholestatic pattern enzyme elevation. Histomorphological analysis revealed four main patterns; with the exception of mass forming lesions (pattern 4; n = 8), cases with sinusoidal predominant (pattern 1; n = 12), portal predominant with sinusoidal infiltrates (pattern 2; n = 13) or lobular aggregates (pattern 3; n = 5) demonstrated small to medium lymphocytes resembling a reactive/inflammatory process. In addition, we described two cases of T-cell large granular lymphocytic leukemia that mimicked HSTCL, and a case of aggressive post-transplant lymphoproliferative disorder that developed after chronic Epstein-barr virus (EBV) infection, suggesting the importance of EBV testing in some lymphoma cases. As the largest cohort of T-cell neoplasms in liver, our study provides critical data on disease frequency, distribution, and clinicopathologic features that are essential for accurate diagnosis.
Databáze: OpenAIRE
Externí odkaz: