Ion Channel Gene Therapy for Smooth Muscle Disorders: Relaxing Smooth Muscles to Treat Erectile Dysfunction
| Autor: | Jonathan D. Schiff, Arnold Melman |
|---|---|
| Rok vydání: | 2006 |
| Předmět: |
Male
medicine.medical_specialty Phosphodiesterase Inhibitors Vasodilator Agents Genetic enhancement Molecular Sequence Data Biology Bioinformatics Gene product Erectile Dysfunction Smooth muscle Internal medicine Drug Discovery medicine Humans Large-Conductance Calcium-Activated Potassium Channel alpha Subunits Promoter Regions Genetic Gene Ion channel Base Sequence Muscle Smooth Genetic Therapy medicine.disease Potassium channel Endocrinology Erectile dysfunction Naked DNA Molecular Medicine |
| Zdroj: | ASSAY and Drug Development Technologies. 4:89-95 |
| ISSN: | 1557-8127 1540-658X |
| DOI: | 10.1089/adt.2006.4.89 |
| Popis: | The promise of gene therapy to treat diseases remains largely unfulfilled. Past setbacks and the complexity of the delivery systems used, in terms of both targeting the appropriate cells and inducing expression of products at therapeutic levels, thus far have prevented significant success for gene therapy. Smooth muscle disorders represent a unique target for gene therapy. In many cases, smooth muscle is readily accessible and, to induce a therapeutic effect, will not require very high levels of gene product expression. This allows a lower efficiency of gene transfer to be successful. With these important features in mind, we believe that naked DNA transfer of potassium ion channels represents a novel and successful way to treat smooth muscle disorders. Herein, we present a rationale for treating erectile dysfunction, a smooth muscle disorder of the cavernosal bodies of the penis, with naked DNA gene transfer therapy. By inserting the hSlo gene, which codes for Maxipotassium channels, into smooth muscle cells, we can improve smooth muscle relaxation in the corporal bodies and thus improve erectile function. This method of gene transfer has proven to be safe and effective for erectile dysfunction, and human trials are ongoing. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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