Temozolomide treatment does not affect topiramate and oxcarbazepine plasma concentrations in chronically treated patients with brain tumor-related epilepsy
| Autor: | Bruno Jandolo, Marta Maschio, Manuela Contin, Loredana Dinapoli, Alessia Zarabla, Andrea Pace, Agostino Baruzzi, Alessandra Fabi, Fiorenzo Albani |
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| Přispěvatelé: | Maschio M., Albani F., Jandolo B., Zarabla A., Contin M., Dinapoli L., Fabi A., Pace A., Baruzzi A. |
| Rok vydání: | 2008 |
| Předmět: |
Adult
Male Topiramate Cancer Research medicine.medical_specialty Neurology Urology Brain tumor Oxcarbazepine Fructose Pharmacology Young Adult Epilepsy Temozolomide medicine Humans Antineoplastic Agents Alkylating Brain Neoplasms business.industry Small sample Middle Aged medicine.disease Dacarbazine Carbamazepine Oncology Plasma concentration Anticonvulsants Female Neurology (clinical) business Follow-Up Studies medicine.drug |
| Zdroj: | Journal of Neuro-Oncology. 90:217-221 |
| ISSN: | 1573-7373 0167-594X |
| Popis: | Objective Medical management of brain tumor-related epilepsy is complicated by interactions between antiepileptic and chemotherapeutic drugs. We studied the effect of temozolomide therapy on the disposition of the new antiepileptic drugs topiramate (TPM) or oxcarbazepine (OXC). Methods Fifteen patients chronically treated with TPM or OXC in monotherapy starting a chemotherapeutic treatment with temozolomide were enrolled in the study, of which ten were available for the final analyses. Blood samples were collected before temozolomide treatment (T0), at its end (T7) and after further 1–3 weeks (T14–T28). For each patient, more than one treatment cycle was studied. Topiramate and OXC mono-10-hydroxy derivative (MHD) plasma concentrations were determined by hplc coupled with ion spray mass spectrometer (TPM) or ultraviolet (MHD) detection. Results Mean TPM concentrations were 5.4 ± 2.4 μg/ml at T0 vs. 5.5 ± 2.4 μg/ml at T7 (n = 14), and 5.4 ± 2.4 μg/ml at T0 vs. 5.6 ± 2.8 μg/ml at T14–T28 (n = 14). Mean MHD concentrations were 16.4 ± 7.6 μg at T0 vs. 18.5 ± 9.0 μg/ml at T7 (n = 5), and 16.8 ± 7.0 μg/ml at T0 vs. 18.0 ± 8.7 μg/ml at T14–T28 (n = 8) (all comparisons not statistically significant; Student’s t-test for paired samples). Conclusion Temozolomide treatment did not affect TPM plasma concentrations in chronically treated patients. Data for MHD in OXC-treated patients were similar, but, due to the small sample size, results should be interpreted cautiously.These findings confirm that TPM (and possibly OXC) are a reasonable choice of antiepileptic drug in patients with brain tumor-related epilepsy. |
| Databáze: | OpenAIRE |
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