S-nitrosylation and its role in breast cancer angiogenesis and metastasis
| Autor: | Walter N. Durán, Fabiola A. Sánchez, Francisco Córdova, Pamela Ehrenfeld |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Cancer Research Endothelium Physiology Angiogenesis Nitrosation Clinical Biochemistry Breast Neoplasms 030204 cardiovascular system & hematology medicine.disease_cause Biochemistry Nitric oxide Metastasis Neovascularization 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine medicine Animals Humans Epithelial–mesenchymal transition Neoplasm Metastasis Nitrates Neovascularization Pathologic Chemistry Proteins medicine.disease Extravasation 030104 developmental biology medicine.anatomical_structure Cancer research Endothelium Vascular medicine.symptom Carcinogenesis |
| Zdroj: | Nitric Oxide. 87:52-59 |
| ISSN: | 1089-8603 |
| DOI: | 10.1016/j.niox.2019.03.002 |
| Popis: | S-nitrosylation, the modification by nitric oxide of free sulfhydryl groups in cysteines, has become an important regulatory mechanism in carcinogenesis and metastasis. S-nitrosylation of targets in tumor cells contributes to metastasis regulating epithelial to mesenchymal transition, migration and invasion. In the tumor environment, the role of S-nitrosylation in endothelium has not been addressed; however, the evidence points out that S-nitrosylation of endothelial proteins may regulate angiogenesis, adhesion of tumor cells to the endothelium, intra and extravasation of tumor cells and contribute to metastasis. |
| Databáze: | OpenAIRE |
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