Antioxidant potential of essential oil from Lavandula angustifolia in in vitro and ex vivo cultured liver cells
| Autor: | M Sramkova, Annamária Srančíková, Vladimír Meluš, Zdenka Krajčovičová, Katarína Kozics, Eva Horváthová, E Sedlackova, Martina Melušová |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Cancer Research Antioxidant DNA damage medicine.medical_treatment Pharmacology Antioxidants law.invention 03 medical and health sciences law Botany Oils Volatile medicine Animals Humans Plant Oils Cells Cultured Essential oil Lavandula angustifolia Glutathione Peroxidase biology Superoxide Dismutase Chemistry Hep G2 Cells Glutathione In vitro Rats Oxidative Stress Lavandula 030104 developmental biology Liver Oncology Hepatocytes biology.protein Dismutase Ex vivo Peroxidase |
| Zdroj: | Neoplasma. 64:485-493 |
| ISSN: | 1338-4317 |
| DOI: | 10.4149/neo_2017_401 |
| Popis: | Lavender is a commonly used herb in traditional medicine in Asia and Europe. It has been reported to be an effective medical plant in treating inflammation, depression and stress, thanks to its sedative and anxiolytic action, thrombotic, and antimicrobial properties. In the present study we investigated the protective effects of essential oil from Lavandula angustifolia (LO) against hydrogen peroxide and tert-butyl hydroperoxide -induced DNA damage. Also the effects of LO on the levels of enzymatic and non-enzymatic antioxidants (SOD-superoxide dismutase, GPx-glutathione peroxidase, GSH-glutathione) were evaluated in in vitro (human hepatoma cell line HepG2) and in ex vivo (freshly isolated rat hepatocytes) systems. The results showed that the oxidant-induced DNA lesions were significantly reduced in both systems pre-treated with the Lavandula angustifolia. The observed DNA-protective activity could be explained by both elevation of GPx activity in cells pre-treated with LO and antioxidant activity of LO. |
| Databáze: | OpenAIRE |
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