Stem cell therapy for neurological disorders: A focus on aging
| Autor: | Sydney Zarriello, Elliot G. Neal, Anna Gorsky, Cesar V. Borlongan, Hung Nguyen, Mira Rajani, Chase Kingsbury, Cannon Nelson, Alexandreya B. Coats |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Aging Traumatic brain injury medicine.medical_treatment Cell- and Tissue-Based Therapy Disease Bioinformatics Article lcsh:RC321-571 Cell therapy 03 medical and health sciences 0302 clinical medicine Atrophy medicine Animals Humans Amyotrophic lateral sclerosis Age-related brain disorders lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry business.industry Stem Cells Multiple sclerosis Neurodegenerative diseases Stem-cell therapy medicine.disease Cell-therapy Stroke 030104 developmental biology Neurology Nervous System Diseases Stem cell business 030217 neurology & neurosurgery |
| Zdroj: | Neurobiol Dis Neurobiology of Disease, Vol 126, Iss, Pp 85-104 (2019) |
| ISSN: | 0969-9961 |
| DOI: | 10.1016/j.nbd.2018.09.011 |
| Popis: | Age-related neurological disorders continue to pose a significant societal and economic burden. Aging is a complex phenomenon that affects many aspects of the human body. Specifically, aging can have detrimental effects on the progression of brain diseases and endogenous stem cells. Stem cell therapies possess promising potential to mitigate the neurological symptoms of such diseases. However, aging presents a major obstacle for maximum efficacy of these treatments. In this review, we discuss current preclinical and clinical literature to highlight the interactions between aging, stem cell therapy, and the progression of major neurological disease states such as Parkinson’s disease, Huntington’s disease, stroke, traumatic brain injury, amyotrophic lateral sclerosis, multiple sclerosis, and multiple system atrophy. We raise important questions to guide future research and advance novel treatment options. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect