Comparative efficacy and safety of axitinib versus sorafenib in metastatic renal cell carcinoma: a systematic review and meta-analysis
| Autor: | Libo Man, Hai Wang, Jian-wei Wang, Guizhong Li, Guang-lin Huang |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Sorafenib
Oncology medicine.medical_specialty efficacy axitinib Review metastatic renal cell carcinoma law.invention 03 medical and health sciences 0302 clinical medicine Randomized controlled trial Renal cell carcinoma law Internal medicine medicine Pharmacology (medical) Progression-free survival Adverse effect business.industry Hazard ratio medicine.disease adverse events phase III study Axitinib 030220 oncology & carcinogenesis Meta-analysis 030221 ophthalmology & optometry sorafenib business progression-free survival medicine.drug |
| Zdroj: | OncoTargets and therapy |
| ISSN: | 1178-6930 |
| Popis: | OBJECTIVE This study was performed to evaluate the comparative efficacy and safety of axitinib and sorafenib in the therapy of metastatic renal cell carcinoma. MATERIALS AND METHODS Eligible studies were searched from PubMed, Embase, and Future Medicine databases. The pooled hazard ratios and relative risk ratios (RRs) were calculated by using Stata 12.0 software. RESULTS A total of 1,011 patients qualified to participate in this Phase III study that included randomized controlled trials. Meta-analysis results showed that axitinib was more highly and significantly associated with a survival benefit in the independently assessed progression-free survival in comparison to sorafenib. The values of RR of the objective response rate and disease control rate were also significantly different. Results of the analysis of adverse events concerning hypertension and hypothyroidism demonstrated that the values of RR were significantly higher in the axitinib group and lower risks were established in the patients treated with axitinib. CONCLUSION Therefore, axitinib was a better treatment option for metastatic renal cell carcinoma treatment than sorafenib, especially after failure of prior systemic therapies. This analysis revealed that axitinib had higher risks of hypertension and hypothyroidism and lower risks of rash and palmar-plantar erythrodysesthesia. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|