H1 but not H2 histamine antagonist receptors mediate anxiety-related behaviors and emotional memory deficit in mice subjected to elevated plus-maze testing
| Autor: | K.R. Serafim, Rosana Mattioli, Azair Canto-de-Souza, Marcos Seizo Kishi |
|---|---|
| Přispěvatelé: | Universidade Federal de São Carlos (UFSCar), Universidade Estadual Paulista (Unesp) |
| Jazyk: | angličtina |
| Rok vydání: | 2013 |
| Předmět: |
medicine.medical_specialty
Elevated plus maze Chlorpheniramine Physiology medicine.medical_treatment Immunology Biophysics Histamine H1 receptor Anxiety Biochemistry Zolantidine chemistry.chemical_compound Histamine H2 receptor Memory Internal medicine medicine General Pharmacology Toxicology and Pharmaceutics Receptor Saline lcsh:QH301-705.5 lcsh:R5-920 business.industry General Neuroscience Antagonist Cell Biology General Medicine Chlorphenamine Endocrinology chemistry lcsh:Biology (General) Anesthesia business lcsh:Medicine (General) Histamine Elevated plus-maze medicine.drug |
| Zdroj: | Brazilian Journal of Medical and Biological Research, Vol 46, Iss 5, Pp 440-446 (2013) SciELO Repositório Institucional da UNESP Universidade Estadual Paulista (UNESP) instacron:UNESP Brazilian Journal of Medical and Biological Research, Volume: 46, Issue: 5, Pages: 440-446, Published: 19 APR 2013 Brazilian Journal of Medical and Biological Research v.46 n.5 2013 Brazilian Journal of Medical and Biological Research Associação Brasileira de Divulgação Científica (ABDC) instacron:ABDC |
| ISSN: | 0100-879X |
| Popis: | Submitted by Guilherme Lemeszenski (guilherme@nead.unesp.br) on 2013-08-22T18:52:53Z No. of bitstreams: 1 S0100-879X2013000500440.pdf: 152239 bytes, checksum: 4029ee458cb590ddd1cf43fa9993b549 (MD5) Made available in DSpace on 2013-08-22T18:52:53Z (GMT). No. of bitstreams: 1 S0100-879X2013000500440.pdf: 152239 bytes, checksum: 4029ee458cb590ddd1cf43fa9993b549 (MD5) Previous issue date: 2013-05-01 Made available in DSpace on 2013-09-30T18:14:59Z (GMT). No. of bitstreams: 2 S0100-879X2013000500440.pdf: 152239 bytes, checksum: 4029ee458cb590ddd1cf43fa9993b549 (MD5) S0100-879X2013000500440.pdf.txt: 30406 bytes, checksum: affa9eab543e6dee73f30079deb2d8f2 (MD5) Previous issue date: 2013-05-01 Submitted by Vitor Silverio Rodrigues (vitorsrodrigues@reitoria.unesp.br) on 2014-05-20T13:31:24Z No. of bitstreams: 2 S0100-879X2013000500440.pdf: 152239 bytes, checksum: 4029ee458cb590ddd1cf43fa9993b549 (MD5) S0100-879X2013000500440.pdf.txt: 30406 bytes, checksum: affa9eab543e6dee73f30079deb2d8f2 (MD5) Made available in DSpace on 2014-05-20T13:31:24Z (GMT). No. of bitstreams: 2 S0100-879X2013000500440.pdf: 152239 bytes, checksum: 4029ee458cb590ddd1cf43fa9993b549 (MD5) S0100-879X2013000500440.pdf.txt: 30406 bytes, checksum: affa9eab543e6dee73f30079deb2d8f2 (MD5) Previous issue date: 2013-05-01 This study investigated the role of H1 and H2 receptors in anxiety and the retrieval of emotional memory using a Trial 1/Trial 2 (T1/T2) protocol in an elevated plus-maze (EPM). Tests were performed on 2 consecutive days, designated T1 and T2. Before T1, the mice received intraperitoneal injections of saline (SAL), 20 mg/kg zolantidine (ZOL, an H2 receptor antagonist), or 8.0 or 16 mg/kg chlorpheniramine (CPA, an H1 receptor antagonist). After 40 min, they were subjected to the EPM test. In T2 (24 h later), each group was subdivided into two additional groups, and the animals from each group were re-injected with SAL or one of the drugs. In T1, the Student t-test showed no difference between the SAL and ZOL or 8 mg/kg CPA groups with respect to the percentages of open arm entries (%OAE) and open arm time (%OAT). However, administration of CPA at the highest dose of 16 mg/kg decreased %OAE and %OAT, but not locomotor activity, indicating anxiogenic-like behavior. Emotional memory, as revealed by a reduction in open arm exploration between the two trials, was observed in all experimental groups, indicating that ZOL and 8 mg/kg CPA did not affect emotional memory, whereas CPA at the highest dose affected acquisition and consolidation, but not retrieval of memory. Taken together, these results suggest that H1 receptor, but not H2, is implicated in anxiety-like behavior and in emotional memory acquisition and consolidation deficits in mice subjected to EPM testing. Universidade Federal de São Carlos (UFSCar) Centro de Ciências Biológicas e da Saúde Departamento de Fisioterapia Universidade Estadual Paulista Faculdade de Filosofia e Ciências Departamento de Fisioterapia e Terapia Ocupacional Universidade Federal de São Carlos (UFSCar) Centro de Educação e Ciências Humanas Departamento de Psicologia Universidade Federal de São Carlos (UFSCar) Programa de Pós-Graduação em Ciências Fisiológicas (UFSCar/UNESP) Universidade Federal de São Carlos (UFSCar) Programa de Pós-Graduação em Psicologia Universidade Estadual Paulista Faculdade de Filosofia e Ciências Departamento de Fisioterapia e Terapia Ocupacional Universidade Federal de São Carlos (UFSCar) Programa de Pós-Graduação em Ciências Fisiológicas (UFSCar/UNESP) |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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