Serum Uric Acid in Essential Hypertension: An Indicator of Renal Vascular Involvement
| Autor: | Daniel H. Suarez, Edward D. Frohlich, Franz H. Messerli, Gerardo G. Aristimuno, Gerald R. Dreslinski |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Adult
Male medicine.medical_specialty Urology Renal function Kidney urologic and male genital diseases Essential hypertension chemistry.chemical_compound Internal Medicine medicine Intravascular volume status Humans Hyperuricemia Nephrosclerosis business.industry General Medicine medicine.disease Uric Acid medicine.anatomical_structure chemistry Regional Blood Flow Renal blood flow Hypertension Vascular resistance Uric acid Vascular Resistance business Glomerular Filtration Rate |
| Zdroj: | Annals of Internal Medicine. 93:817 |
| ISSN: | 0003-4819 |
| DOI: | 10.7326/0003-4819-93-6-817 |
| Popis: | We measured glomerular filtration rate, renal and systemic hemodynamics, and intravascular volume in normotensive subjects and in borderline and established essential hypertensive patients classified according to serum uric acid level. Renal blood flow was lower and renal vascular and total peripheral resistances were increased in patients with high uric acid levels (p < 0.02). Serum uric acid concentration correlated inversely with renal blood flow/m2 body surface area (r = -0.45, p < 0.001) and directly with renal vascular (r = 0.41, p < 0.001) and total (r = 0.38, p < 0.001) resistance. Cardiac output, heart rate, and intravascular volume as well as glomerular filtration rate showed no uric-acid-department pattern. Mild asymptomatic hyperuricemia, therefore, was associated with decreased renal blood flow without affecting glomerular filtration rate. Increased renal vascular and total peripheral resistances reflecting renal and systemic hypertensive vascular disease paralleled the rising serum uric acid levels. These data suggest that heretofore unexplained hyperuricemia in patients with essential hypertension most likely reflects early renal vascular involvement, specially, nephrosclerosis. |
| Databáze: | OpenAIRE |
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