Regenerative medicine in lower limb reconstruction
| Autor: | Howard C. Tribe, Josephine K. McEwan, Neal Jacobs, Richard O.C. Oreffo, Douglas G. Dunlop, Amir A Qureshi, Nicholas Hancock |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
Embryology
medicine.medical_specialty medicine.medical_treatment Nonunion Biomedical Engineering Regenerative Medicine Regenerative medicine Bone tissue engineering Lower limb 03 medical and health sciences 0302 clinical medicine Form and function Specialized connective tissue medicine Animals Humans 030212 general & internal medicine 030222 orthopedics Tissue Engineering business.industry medicine.disease Surgery Lower Extremity Amputation Orthopedic surgery Bone Diseases business |
| Zdroj: | Regenerative Medicine. 13:477-490 |
| ISSN: | 1746-076X 1746-0751 |
| DOI: | 10.2217/rme-2018-0011 |
| Popis: | Bone is a highly specialized connective tissue and has a rare quality as one of the few tissues that can repair without a scar to regain pre-injury structure and function. Despite the excellent healing capacity of bone, tumor, infection, trauma and surgery can lead to significant bone loss requiring skeletal augmentation. Bone loss in the lower limb poses a complex clinical problem, requiring reconstructive techniques to restore form and function. In the past, amputation may have been the only option; however, there is now an array of reconstructive possibilities and cellular therapies available to salvage a limb. In this review, we will evaluate current applications of bone tissue engineering techniques in limb reconstruction and identify potential strategies for future work. |
| Databáze: | OpenAIRE |
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