Rearrangements of DNA-protien interactions in animal cells coupled with growth quiescence transitions
| Autor: | Anatoly V. Lichtenstein, Nikolai I. Sjakste, Shapot Vs, Mikhail M. Zaboykin |
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| Rok vydání: | 1982 |
| Předmět: |
Biology
Mice chemistry.chemical_compound Liver Neoplasms Experimental Genetics medicine Animals Humans Moiety Transition (genetics) Cell Cycle DNA Fibroblasts Cell cycle Embryo Mammalian Chromatin Liver Regeneration Rats Nucleoprotein Cell biology Cell nucleus Nucleoproteins medicine.anatomical_structure Liver chemistry Deoxyribonuclease I HeLa Cells |
| Zdroj: | Europe PubMed Central |
| ISSN: | 1362-4962 0305-1048 |
| DOI: | 10.1093/nar/10.3.1127 |
| Popis: | Overall DNA-protein interactions in animal cells undergo drastic changes coupled with cellular transitions from quiescence to growth and reversely as revealed by nucleoprotein-Celite chromatography. DNA of chromatin was found to exist in one of the two sharply distinct alternative forms, namely, either tightly or weakly bound to protein moiety. These forms are specific for cycling and quiescent cells, respectively. The tight DNA-protein interactions characterize all cycling cells independent of the cell cycle phase. Transition of DNA of cycling cells from one form to another was observed as a result of treatment of isolated nuclei with DNase I. |
| Databáze: | OpenAIRE |
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