Radiofrequency ablation plus drug-eluting beads transcatheter arterial chemoembolization for the treatment of single large hepatocellular carcinoma
| Autor: | Antonio Gasbarrini, Lorenzo Bonomo, Roberto Iezzi, Antonio Grieco, Martina Montagna, Eleonora Annicchiarico, Salvatore Agnes, Massimo Siciliano, Felice Giuliante, Anna Maria De Gaetano, Gian Lodovico Rapaccini, Maria Chiara Campanale, Antonio Saviano, Michele La Torre, Maurizio Pompili, Valentina Cesario |
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| Rok vydání: | 2014 |
| Předmět: |
Male
medicine.medical_specialty Carcinoma Hepatocellular Radiofrequency ablation medicine.medical_treatment Population Urology Pilot Projects Gastroenterology law.invention law Internal medicine medicine Humans Prospective Studies Chemoembolization Therapeutic Transcatheter arterial chemoembolization education Complete response Aged education.field_of_study Hepatology Drug eluting beads business.industry Liver Neoplasms Middle Aged medicine.disease Ablation Combined Modality Therapy Treatment Outcome Hepatocellular carcinoma Catheter Ablation Combined therapy Female Neoplasm Recurrence Local business |
| Zdroj: | Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver. 47(3) |
| ISSN: | 1878-3562 |
| Popis: | Background Our aim was to evaluate the effectiveness of the single-step combined therapy with radiofrequency ablation and drug-eluting beads transarterial chemoembolization in single hepatocellular carcinoma (HCC) larger than 3 cm. Secondary aim was to compare the results with those obtained in a matched population treated with drug-eluting beads transarterial chemoembolization alone. Methods 40 consecutive cirrhotic patients with single HCC were prospectively enrolled and treated. Twenty-three patients had tumours between 3 and 5 cm (Group A), and 17 larger than 5 cm (Group B). Twenty cirrhotic patients with single HCC treated only with chemoembolization formed the control group. Results Complete response at 1 month was achieved in 32/40 tumours (80%). During follow-up, complete response was maintained in 25 patients (25/40, 62.5%), and this rate was higher in Group A (69.6% vs 53%, p = 0.008). The group treated with combined therapy showed a significantly lower 2-year recurrence (48.1% vs 78.2%, p p = 0.004) than the group treated with chemoembolization alone. Conclusions Balloon-occluded-radiofrequency ablation plus drug-eluting beads transarterial chemoembolization is an effective treatment of HCC larger than 3 cm not amenable to surgical resection, providing better results than transarterial chemoembolization alone. The best results are achieved in tumours up to 5 cm. |
| Databáze: | OpenAIRE |
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