Short exposure to intermittent hypoxia increases erythropoietin levels in healthy individuals
| Autor: | Mercedes J Nagel, Sophie Lalande, Sten Stray-Gundersen, Frank Wojan |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Serum erythropoietin Physiology Erythropoietin levels Biochemistry Physiology (medical) Internal medicine Genetics medicine Humans Hypoxia Erythropoietin Molecular Biology business.industry Intermittent hypoxia Hypoxia (medical) Oxygen Endocrinology Healthy individuals medicine.symptom Short exposure business human activities Biotechnology medicine.drug |
| Zdroj: | Journal of Applied Physiology. 130:1955-1960 |
| ISSN: | 1522-1601 8750-7587 |
| DOI: | 10.1152/japplphysiol.00941.2020 |
| Popis: | Few minutes of hypoxic exposure stabilizes hypoxia-inducible factor-1α, resulting in erythropoietin (EPO) gene transcription and production. The objective of this study was to identify the shortest intermittent hypoxia protocol necessary to increase serum EPO levels in healthy individuals. In a first experiment, spontaneous EPO changes under normoxia (NORM) and the EPO response to five 4-min cycles of intermittent hypoxia (IH5) were determined in six individuals. In a second experiment, the EPO response to eight 4-min cycles of intermittent hypoxia (IH8) and 120 min of continuous hypoxia (CONT) was determined in six individuals. All hypoxic protocols were performed at a targeted arterial oxygen saturation of 80%. There was no significant change in EPO levels in response to normoxia or in response to five cycles of intermittent hypoxia (NORM: 9.5 ± 1.8 to 10.5 ± 1.8, IH5: 11.4 ± 2.3 to 13.4 ± 2.1 mU/mL, main effect for time |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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