NF-κB in T-cell Acute Lymphoblastic Leukemia: Oncogenic functions in Leukemic and in Microenvironmental Cells
| Autor: | Nuno R. dos Santos, Ricardo C. da Silva, Mónica T. Fernandes, Marinella N. Ghezzo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Cancer Research
Stromal cell Microenvironment Lymphoma T cell lymphoma Review lcsh:RC254-282 NF-κB 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine NOTCH1 Medicine Gene Transcription factor 030304 developmental biology 0303 health sciences Leukemia business.industry leukemia medicine.disease lcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogens microenvironment Signaling medicine.anatomical_structure Oncology chemistry 030220 oncology & carcinogenesis NF-B Immunology Cancer research Signal transduction business signaling |
| Zdroj: | Cancers, Vol 2, Iss 4, Pp 1838-1860 (2010) Cancers |
| Popis: | Two main NF-κB signaling pathways, canonical and noncanonical, performing distinct functions in organisms have been characterized. Identification of mutations in genes encoding components of these NF-κB signaling pathways in lymphoid malignancies confirmed their key role in leukemogenesis. T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive malignancy of thymocytes that despite significant therapeutic advances can still be fatal. Although mutations in NF-κB genes have not been reported in T-ALL, NF-κB constitutive activation in human T-ALL and in acute T-cell leukemia mouse models has been observed. Although these studies revealed activation of members of both canonical and noncanonical NF-κB pathways in acute T-cell leukemia, only inhibition of canonical NF-κB signaling was shown to impair leukemic T cell growth. Besides playing an important pro-oncogenic role in leukemic T cells, NF-κB signaling also appears to modulate T-cell leukemogenesis through its action in microenvironmental stromal cells. This article reviews recent data on the role of these transcription factors in T-ALL and pinpoints further research crucial to determine the value of NF-κB inhibition as a means to treat T-ALL. info:eu-repo/semantics/publishedVersion |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|