Molecular alterations in non-functioning pituitary adenomas

Autor:	Aldo Ferreira-Hermosillo, Etual Espinosa-Cárdenas, Yorgui Santiago-Andres, Keiko Taniguchi-Ponciano, Sonia Vargas-Chavez, Moisés Mercado, Erick Gómez-Apo, Laura Chávez-Macías, Guadalupe Vargas, Ernesto Sosa, Raúl Peralta, Eduardo Peña-Martínez, Daniel Marrero-Rodríguez, Gloria Silva-Román, Claudia Ramírez-Rentería, Sergio Andonegui-Elguera
Rok vydání:	2020
Předmět:	Adenoma Receptors CXCR4 Cancer Research Pathology medicine.medical_specialty Calcium Channels L-Type Microarray Kruppel-Like Transcription Factors Datasets as Topic Biology Transcriptome Immunophenotyping Biomarkers Tumor Genetics Null cell medicine Humans Pituitary Neoplasms 0501 psychology and cognitive sciences Gene Oligonucleotide Array Sequence Analysis 0505 law Homeodomain Proteins PITX2 05 social sciences Computational Biology General Medicine Phenotype Gene Expression Regulation Neoplastic Oncology Pituitary Gland 050501 criminology Immunohistochemistry Transcription Factors 050104 developmental & child psychology
Zdroj:	Cancer Biomarkers. 28:193-199
ISSN:	1875-8592 1574-0153
Popis:	Background Clinically non-functioning Pituitary Adenomas (NFPA) are among the most common neoplasms of the sellar region. They usually present with compressive symptoms such as headache and visual field defects and not infrequently, are found incidentally. NFPA are classified as gonadotropinomas, null cell adenomas, according to their immunohistochemical phenotype. The molecular alterations responsible for the development of these lesions are incompletely understood, and there is scarce information regarding the molecular alterations and markers. Objective We carried out an in-silico analysis aimed at identifying the molecular alterations in NFPA and to discover new molecular markers. Methods Twenty-three microarray libraries were analyzed. Fourteen correspond to NFPA and 9 to control tissue gland. They were analyzed using Partek Genomic Suite to identify differentially expressed genes and WebGestalt and Metascape to understand the meaning behind the gene lists. Results Pituitary adenomas showed a markedly different transcriptome compared to the non-tumoral gland, regardless of their putative immunophenotype. Genes related to calcium metabolism such as CACNA2D4, immune-related CXCR4, and stem cell-related KLF8 and PITX2 were altered. Conclusions Differentially expressed calcium metabolism and immune-related genes in NFPA represent attractive molecular markers and potential therapeutic targets.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d2a1f07db0de15a73031cdc0230c57e https://doi.org/10.3233/cbm-191121 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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