Pharyngeal flap versus sphincter pharyngoplasty for the treatment of velopharyngeal insufficiency: a meta-analysis
| Autor: | Kevin Cheung, Nick Strumas, Jessica Collins, Forough Farrokhyar |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
medicine.medical_specialty
Velopharyngeal Insufficiency business.industry Speech Intelligibility Odds ratio Confidence interval Surgical Flaps Surgery Cleft Palate medicine.anatomical_structure Velopharyngeal insufficiency Statistical significance Meta-analysis medicine Forest plot Pharyngeal Muscles Sphincter Humans business Child Pharyngeal flap Randomized Controlled Trials as Topic |
| Zdroj: | Journal of plastic, reconstructiveaesthetic surgery : JPRAS. 65(7) |
| ISSN: | 1878-0539 |
| Popis: | Summary Background Velopharyngeal insufficiency (VPI) has been reported in 5–20% of patients following cleft palate repair. Since VPI can limit communication, determining which operative procedure leads to the greatest improvement is of utmost importance. Since there is no consensus, this meta-analysis aims to determine which procedure results in the most significant resolution of VPI. Methods Two independent assessors undertook a literature review for articles that compare procedures aimed at treating VPI. Study quality was determined using validated scales. Level of agreement was assessed using intra-class coalition coefficient analysis. The heterogeneity between studies was evaluated using I 2 and Cochran's Q-statistic. Random effect model analysis and forest plots were used to report a pooled odds ratio (OR) and 95% confidence intervals (CI) for treatment effect. A p -value of 0.05 was considered for statistical significance. Results Two randomised controlled trials (RCTs) comparing pharyngeal flap to sphincter pharyngoplasty were obtained. A total of 133 patients were included, with follow-ups at 3–4 months. The pooled OR was determined to be 2.95 (95% CI: 0.66–13.23) in favour of the pharyngeal flap. Conclusions Based on these RCTs, which currently compose the highest quality data that compares pharyngeal flap versus pharyngoplasty, the pooled treatment effect suggests a possible trend favouring pharyngeal flap. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect