Prognostic value of serum Epstein-Barr virus antibodies in patients with nasopharyngeal carcinoma and undetectable pretreatment Epstein-Barr virus DNA

Autor: Si Yang Wang, Zhi Bin Cheng, Ji Jin Yao, Ya Nan Jin, Wangjian Zhang, Ying Sun, Zhen Yu Qi, Li Lin, Guan Qun Zhou, Fan Zhang
Rok vydání: 2017
Předmět:
0301 basic medicine
Male
Cancer Research
Epstein-Barr Virus Infections
Herpesvirus 4
Human
medicine.disease_cause
Antibodies
Viral
Gastroenterology
0302 clinical medicine
Stage (cooking)
Epstein–Barr virus antibodies
Nasopharyngeal Carcinoma
biology
General Medicine
Middle Aged
Prognosis
viral capsid antigen
Oncology
030220 oncology & carcinogenesis
Female
Original Article
Antibody
Adult
medicine.medical_specialty
Adolescent
Viral capsid antigen
Virus
03 medical and health sciences
Young Adult
Clinical Research
Internal medicine
medicine
otorhinolaryngologic diseases
Humans
In patient
prognostic value
Early antigen
Aged
Neoplasm Staging
business.industry
Carcinoma
Nasopharyngeal Neoplasms
Original Articles
medicine.disease
Epstein–Barr virus
Virology
Survival Analysis
stomatognathic diseases
030104 developmental biology
Nasopharyngeal carcinoma
biology.protein
Capsid Proteins
business
Zdroj: Cancer Science
ISSN: 1349-7006
Popis: Epstein–Barr virus (EBV) is closely associated with nasopharyngeal carcinoma (NPC). Serum IgA antibodies against early antigen (EA‐IgA) and viral capsid antigen (VCA‐IgA) are the most commonly used to screen for NPC in endemic areas. However, the prognostic value of serum EA‐IgA and VCA‐IgA in patients with NPC is less clear. We hypothesize that serum EA‐IgA and VCA‐IgA levels have prognostic impact for survival outcomes in NPC patients with undetectable pretreatment EBV (pEBV) DNA. In this series, 334 patients with non‐metastatic NPC and undetectable pEBV DNA were included. Serum EA‐IgA and VCA‐IgA were determined by ELISA. After analysis, serum EA‐IgA and VCA‐IgA loads correlated positively with T, N, and overall stage (all P 1:120 had significantly inferior 5‐year progression‐free survival (80.4% vs 89.6%, P = 0.025), distant metastasis‐free survival (88.4% vs 94.8%, P = 0.050), and locoregional relapse‐free survival (88.4% vs 95.6%, P = 0.023; log–rank test). Multivariable analyses revealed that N stage was the only independent prognostic factor (all P
Databáze: OpenAIRE
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