Recombination analysis based on the HAstV-2 and HAstV-4 complete genomes
| Autor: | Daria A. Sedelnikova, Igor V. Babkin, Nina V. Tikunova, Artem Tikunov, Elena Zhirakovskaia |
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| Rok vydání: | 2013 |
| Předmět: |
Microbiology (medical)
Genome Viral Biology Microbiology Genome law.invention Astrovirus Russia Feces law Phylogenetics Astroviridae Infections Genotype Genetics Humans Child Molecular Biology Ecology Evolution Behavior and Systematics Phylogeny Recombination Genetic biology.organism_classification Virology Infectious Diseases Viral evolution Recombinant DNA Recombination Mamastrovirus |
| Zdroj: | Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases. 22 |
| ISSN: | 1567-7257 |
| Popis: | Complete genome sequences of previously unstudied human astrovirus subgenotypes - HAstV-2a and HAstV-2c - and two isolates of a rare genotype HAstV-4 have been determined. These isolates were recovered from fecal samples of young children hospitalized with acute intestinal infections in Novosibirsk (Russia). Three of the four sequenced isolates (HAstV-2a, HAstV-2c, and HAstV-4) are recombinants. It has been shown that all known HAstV-2 genomes have emerged via recombination; the HAstV-1 and HAstV-4 genotypes contain both recombinant and non-recombinant isolates; and all HAstV-3, HAstV-5, and HAstV-6 whole-genome sequences display no reliable signs of recombination. The average mutation accumulation rate has been determined based on an extended ORF2 fragment and amounts to 1.0×10(-3) substitutions per site per year. The evolutionary chronology of current HAstV genotypes has been reconstructed. |
| Databáze: | OpenAIRE |
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