Control of Chronic Otitis Media and Sensorineural Hearing Loss in C3H/HeJ Mice: Glucocorticoids Vs Mineralocorticoids
| Autor: | Dennis R. Trune, Jacqueline M. DeGagne, Carol J. MacArthur, J. Beth Kempton |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
medicine.medical_specialty
Hearing loss Hearing Loss Sensorineural Prednisolone Fludrocortisone Anti-Inflammatory Agents Physiology Dexamethasone Article Mice 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Mineralocorticoids Internal medicine Evoked Potentials Auditory Brain Stem medicine Animals 030223 otorhinolaryngology Aldosterone Glucocorticoids Mice Inbred C3H business.industry medicine.disease Otitis Media Endocrinology Otorhinolaryngology chemistry Sample size determination 030220 oncology & carcinogenesis Chronic Disease Surgery Sensorineural hearing loss sense organs Analysis of variance medicine.symptom business medicine.drug |
| Zdroj: | Otolaryngology–Head and Neck Surgery. 139:646-653 |
| ISSN: | 1097-6817 0194-5998 |
| Popis: | The impact of glucocorticoids and mineralocorticoids on chronic otitis media (COM) in toll-like receptor 4-deficient C3H/HeJ mice was investigated.To evaluate control of COM by steroids with differences in their anti-inflammatory (prednisolone, dexamethasone), and fluid absorption functions (fludrocortisone, aldosterone). A minimum sample size of five animals for each group was required based on power analysis calculations. Sample sizes ranged from 7 to 17 mice per treatment group.Auditory brain stem response (ABR) thresholds were performed at baseline, 2 weeks and 4 weeks. Histopathologic test results were evaluated on all mice ears at the end of the study.Analysis of variance (ANOVA) of ABR threshold change showed significant treatment effects (P0.05) by both steroid types at all time intervals and ABR frequencies except 4 weeks/8 kHz. Histologic assessment showed prednisolone-treated mice (62%) had a higher rate of clearance of middle and inner ear inflammation than control mice (4%).It was concluded that steroid treatments can improve the physiology of chronic middle and inner ear disease seen with COM. |
| Databáze: | OpenAIRE |
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