Specific cholinergic destruction in the basal magnocellular necleus and impaired passive avoidance behavior of rodents
| Autor: | Sadao Shiosaka, Mikako Ikeda, Y. Kudo, Shozo Matano, T. Honjoh, Hirohiko Ohta, Masaya Tohyama, M. Shoji, Kazunori Imaizumi, Yasuhide Lee |
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| Rok vydání: | 1991 |
| Předmět: |
Male
Receptors Cell Surface Receptors Nerve Growth Factor Nucleus basalis Choline O-Acetyltransferase Injections Mice Basal (phylogenetics) Degenerative disease Parasympathetic Nervous System Avoidance Learning medicine Animals Diphtheria Toxin Nerve Growth Factors Cholinergic neuron Molecular Biology Cerebral Cortex Neurons Medulla Oblongata Basal forebrain Behavior Animal Histocytochemistry business.industry General Neuroscience fungi Brain Rats Inbred Strains medicine.disease Immunohistochemistry Rats Nerve growth factor nervous system Cholinergic Neurology (clinical) Alzheimer's disease business Neuroscience Developmental Biology |
| Zdroj: | Brain Research. 551:36-43 |
| ISSN: | 0006-8993 |
| DOI: | 10.1016/0006-8993(91)90910-n |
| Popis: | A nerve growth factor (NGF)-diphtheria toxin conjugate (NGDT) was found to selectively abolish or depress the activity of NGF receptor-bearing cholinergic neurons of the basal magnocellular nucleus (BMN). Bilateral cortical injections of NGDT impaired the retention of passive avoidance behavior in mice. A memory deficit was also revealed when cortical injections of NGDT were administered after the acquisition of a passive avoidance response. Thus, retrograde destruction of BMN cholinergic neurons by the cortical injection of NGDT interfered with both learning and memory processes. The animal model outlined here should be useful in analyzing the pathogenesis of Alzheimer's disease and the functions of the cholinergic system in the BMN. |
| Databáze: | OpenAIRE |
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