Biological equivalent dose assessment of the consequences of hypofractionated radiotherapy
| Autor: | S.J Khaksar, P Finst, Bleddyn Jones, Roger G. Dale |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Hypofractionated Radiotherapy
Cancer Research Radiation Radiobiology Equivalent dose business.industry medicine.medical_treatment Dose fractionation Models Biological Effective dose (radiation) Radiation therapy Oncology Linear Models medicine Relative biological effectiveness Radiology Nuclear Medicine and imaging Dose Fractionation Radiation Nuclear medicine business Radiation treatment planning Algorithms Relative Biological Effectiveness |
| Zdroj: | International Journal of Radiation Oncology*Biology*Physics. 47:1379-1384 |
| ISSN: | 0360-3016 |
| DOI: | 10.1016/s0360-3016(00)00571-x |
| Popis: | Purpose: To investigate the changes in biological effective dose (BED) that occur in high-dose regions within a target volume when radiotherapy is hypofractionated. Methods and Materials: By comparing a standard prescription of 2 Gy per fraction that is matched to give the same BED as a hypofractionated schedule at a standard intersectional prescription point, the BED increments for late-tissue effects at a higher dose region within the planning target volume (PTV) are compared. The alternative approach of BED matching between a conventional and hypofractionated schedule at the high-dose region is also considered. The results are presented as a sequence of calculations that can be understood by practicing radiation oncologists and in graphical form. Results: The BED increment at the high-dose region is marginally increased by hypofractionation, although the latter effect is relatively small: up to 5% additional BED due to hypofractionation for a 20% increase in physical dose when the prescribed fraction size is 6–7 Gy. BED matching for late effects between a conventional and hypofractionated schedule at the high-dose region produces lower BED values throughout the remaining PTV, but at the expense of a reduced tumor control BED. Conclusion: Clinical trials that use BED isoeffect matching for late reacting tissue effects to design a hypofractioned test schedule should include comprehensive calculations of the likely BED in high-dose regions. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|