First-trimester free beta (hCG) screening for Down syndrome
| Autor: | Kenneth L. Garver, James N. Macri, André Boué, Françoise Muller, Kevin Spencer, Philip D. Buchanan, David A. Aitken |
|---|---|
| Rok vydání: | 1993 |
| Předmět: |
medicine.medical_specialty
Down syndrome Aneuploidy Gestational Age Chorionic Gonadotropin Double-Blind Method Pregnancy Prenatal Diagnosis medicine Humans Mass Screening Chorionic Gonadotropin beta Subunit Human Genetics (clinical) Retrospective Studies Gynecology Fetus biology Obstetrics Obstetrics and Gynecology Gestational age medicine.disease Peptide Fragments Pregnancy Complications Pregnancy Trimester First biology.protein Gestation Female Down Syndrome Trisomy Biomarkers ATP synthase alpha/beta subunits |
| Zdroj: | Prenatal Diagnosis. 13:557-562 |
| ISSN: | 1097-0223 0197-3851 |
| DOI: | 10.1002/pd.1970130704 |
| Popis: | Maternal serum free beta (hCG) levels are elevated (median 2.20 MOM) in the first trimester of pregnancy in 38 Down syndrome cases as compared with appropriate controls. This observation may form the basis for its use as a marker in screening for Down syndrome in the first trimester. Altered levels of the free beta analyte are observed in pregnancy conditions or complications other than Down syndrome. |
| Databáze: | OpenAIRE |
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