Lead-Discovery of bis-Aromatic Alkynes: A Novel Class of Herbicides

Autor:	Arthur Steiger, Martin Zeller, Jutta Glock, Soan Cheng, G. Wayne Craig, Peter Renold, Hans Ulrich Haas, Martin Eberle, William Lutz, Jürg Ehrler, Evelyne Sieger, Adrian Alberto Friedmann, Thomas Vettiger, James Allen, Renold Chollet, Hans-Jürg Widmer, Olivier Jacob, Peter D. J. Grootenhuis, Thierry Niderman, Mafalda Nina, Marian Valentini, Bondy Steven Scott, Hans Brunner, Julie E. Penzotti, Markus Walti, Comer Daniel Dennis, Grit Laue, Klaus Kreuz
Jazyk:	němčina
Rok vydání:	2008
Předmět:	Agrochemical business.industry Chemistry Field data Sonogashira coupling Combinatorial chemistry General Medicine General Chemistry Discovery Crop protection Lead (geology) Alkyne template business Agrochemicals QD1-999
Zdroj:	CHIMIA, Vol 62, Iss 1-2 (2008)
ISSN:	2673-2424 0009-4293
Popis:	The search for new active molecules with novel modes of action and desirable physical properties is an ongoing endeavour. This publication describes the follow-up chemistry of a biological hit discovered in the screening system of Novartis Crop Protection, the legacy agrochemical parent of Syngenta Crop Protection. This chemistry was optimized through classical synthetic methods and automated parallel synthesis with coverage of important physical properties such as lipophilicity or Clog P and solubility. Preliminary biological activity from the greenhouse and field data with symptomology is presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d231864cb6d3e1de13ce05a89d9970e https://chimia.ch/chimia/article/view/4428 Zobrazit plný text záznamu