Comparison of three methods for cyclosporine area under the curve monitoring calculations
| Autor: | Wong-Chin M, Lum Bl, Cooney Gf, Dalere Gm |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Pharmacology
medicine.medical_specialty Adolescent business.industry Area under the curve Kidney Transplantation Confidence interval Therapeutic monitoring Surgery Child Preschool medicine Renal allograft Cyclosporine Humans Pharmacology (medical) Drug Monitoring Dose rate Nuclear medicine business Child |
| Zdroj: | Therapeutic drug monitoring. 17(3) |
| ISSN: | 0163-4356 |
| Popis: | A method of therapeutic monitoring of cyclosporine by using area under the curve (AUC) has been previously proposed. However, different mathematical methods of calculating AUC may produce different results. We compared three methods of calculating whole blood 12-h AUC of cyclosporine A (CsA) at steady state in 16 pediatric renal allograft recipients. The linear trapezoidal method tended to significantly overestimate AUC when compared with a method combining linear and log trapezoidal methods, or the Lagrange technique combined with the logarithmic trapezoidal method, producing mean differences of 13.8 ng * h/ml [95% confidence interval (CI), 7.3-20.3] and 12.8 ng * h/ml [95% CI, 7.3-18.3], respectively. However, these differences appear to be of little clinical significance because they comprised |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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