Comparative efficacy of acid reflux inhibition by drug therapy in reflux esophagitis
| Autor: | Nishioka T, Matsuzaki T, Tsutomu Horikoshi, Tsuneo Ohwada, Motoyasu Kusano, Setsuo Kobayashi, Munetoshi Toki, Toshikazu Sekiguchi, Masashi Sugiyama |
|---|---|
| Rok vydání: | 1991 |
| Předmět: |
Adult
Male medicine.medical_specialty medicine.drug_class medicine.medical_treatment Prokinetic agent Proton-pump inhibitor Pharmacology Gastroenterology Esophagus Piperidines Internal medicine medicine Humans Reflux esophagitis Esophagitis Peptic Omeprazole Aged Monitoring Physiologic Cisapride business.industry Stomach Reflux Hydrogen-Ion Concentration Famotidine medicine.anatomical_structure Chronic Disease Female Serotonin Antagonists business medicine.drug |
| Zdroj: | Gastroenterologia Japonica. 26:137-144 |
| ISSN: | 0435-1339 |
| DOI: | 10.1007/bf02811071 |
| Popis: | The advent of histamine H2 receptor antagonists (H2-RA) has allowed the treatment of reflux esophagitis (RE) to be controlled over a relatively long term. The authors have experienced some cases resistant to H2-RA, but it was revealed that these cases can be successfully treated with proton pump inhibitors. It has been suggested that esophagogastric dysmotility can lead to RE. RE has been treated for many years by using GI-prokinetic agents, which theoretically inhibit acid reflux and improve esophageal acid clearance. In order to compare the effects on acid reflux of an H2-RA (famotidine), a proton pump inhibitor (omeprazole) and a GI-prokinetic agent (cisapride), we measured the 24-hour pH in the esophagus and stomach simultaneously, before and after treatment in 17 patients with RE. It was found that the proton pump inhibitor was the most effective drug for inhibiting esophageal acidification, followed by famotidine and then cisapride. Furthermore, we found that cisapride often actually exacerbated acid reflux. The differences in inhibitory effects on acidification allowed us to draw conclusions regarding the treatment of RE. It was concluded that the stronger the inhibitory effect of a drug on acid secretion, the more useful it was in the treatment of RE. The GI-prokinetic drug did not inhibit acid reflux as much as we had expected. |
| Databáze: | OpenAIRE |
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