Preparation of benzolactams by Pd(OAc)2-catalyzed direct aromatic carbonylation

Autor:	Kazuhiko Orito, Satoshi Yamashita, Akiyoshi Horibata, Motoki Yuguchi, Hideo Nagasaki, Harumi Ushito, Takatoshi Nakamura, Masao Tokuda
Rok vydání:	2004
Předmět:	Bicyclic molecule Chemistry General Medicine General Chemistry Biochemistry Medicinal chemistry Catalysis Atmosphere Colloid and Surface Chemistry Polymer chemistry Catalyst selectivity Organic chemistry Carbonylation
Zdroj:	Journal of the American Chemical Society. 126(44)
ISSN:	0002-7863
Popis:	We developed a new method for Pd(II)-catalyzed direct aromatic carbonylation in a phosphine-free catalytic system using Pd(OAc)2 and Cu(OAc)2 in an atmosphere of CO gas containing air. The carbonylation proceeded with ortho-palladation, inducing a remarkable site selectivity to afford a variety of five- or six-membered benzolactams from secondary omega-arylalkylamines, such as N-alkylbenzylamines or N-alkylphenethylamines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d1bb88e4522a2b32291976b995f57b2 https://pubmed.ncbi.nlm.nih.gov/15521739 Zobrazit plný text záznamu