A new flavonol from the kino of Eucalyptus citriodora
| Autor: | Wei-Jing Hung, Shwu-Woan Lee, Zong-Tsi Chen |
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| Rok vydání: | 2016 |
| Předmět: |
Spectrometry
Mass Electrospray Ionization Magnetic Resonance Spectroscopy Flavonols Stereochemistry Positive control Plant Science Aromadendrin 01 natural sciences Biochemistry Antioxidants Analytical Chemistry chemistry.chemical_compound Arachidonate 15-Lipoxygenase Lipoxygenase Inhibitors IC50 Eucalyptus 010401 analytical chemistry Organic Chemistry 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry Eucalyptus citriodora Quercetin Kaempferol Two-dimensional nuclear magnetic resonance spectroscopy |
| DOI: | 10.6084/m9.figshare.3490364.v1 |
| Popis: | A new flavonol, 6-[1-(p-hydroxyphenyl)ethyl]rhamnocitrin (3) together with two known compounds, kaempferol (4) and 7-O-methyl aromadendrin (5) were isolated from the kino of Eucalyptus citriodora and their structures were elucidated on the basis of spectroscopic methods including 2D NMR spectra. Rhamnocitrin (1), 6-[1-(p-hydroxyphenyl)ethyl]-7-O-methyl aromadendrin (2), previously isolated from this plant and compounds 3−5 were tested for inhibitory activity against 15-lipoxygenase. All compounds exhibited moderate to strong inhibitory activities, of which compounds 2, 3 and 5 showed stronger inhibitory activity (IC50 19.7 ± 0.5, 29.3 ± 0.9 and 31.4 ± 1.0 μM, respectively) than the positive control quercetin (IC50 37.5 ± 0.8 μM). |
| Databáze: | OpenAIRE |
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