Reaction of anthranilic acid amides with cyclic anhydrides

Autor:	O. S. Krys’kiv, L. A. Shemchuk, V. P. Chernykh
Rok vydání:	2006
Předmět:	chemistry.chemical_compound Acetic anhydride chemistry Amide Organic Chemistry Microwave irradiation Anthranilic acid Intramolecular cyclization Organic chemistry General Medicine Medicinal chemistry Sodium acetate
Zdroj:	Russian Journal of Organic Chemistry. 42:382-387
ISSN:	1608-3393 1070-4280
DOI:	10.1134/s1070428006030079
Popis:	Anthranilic acid amide reacts with cyclic anhydrides to give the corresponding N-acyl derivatives at the amino group, while analogous reactions of o-aminobenzohydroxamic acid lead lead to formation of 3-hydroxy-quinazolin-4-ones under mild conditions. N-Acyl derivatives of anthranilic acid amide undergo intramolecular cyclization to imides on microwave irradiation or on melting, and their treatment with acetic anhydride in the presence of sodium acetate on heating yields quinazolin-4-ones.
Databáze:	OpenAIRE
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