The transcriptional role of PML and the nuclear body
| Autor: | Sue Zhong, Pier Paolo Pandolfi, Paolo Salomoni |
|---|---|
| Rok vydání: | 2000 |
| Předmět: |
Cell Nucleus
Protein PML PML nuclear body Transcription Genetic biology Tumor Suppressor Proteins viruses Nuclear Proteins virus diseases Cell Biology Neoplasm Proteins Cell biology RING finger domain Nuclear body Promyelocytic leukemia protein Transcription (biology) Gene expression biology.protein Animals CREB-binding protein Transcription Factors |
| Zdroj: | Nature Cell Biology. 2:E85-E90 |
| ISSN: | 1476-4679 1465-7392 |
| DOI: | 10.1038/35010583 |
| Popis: | The PML gene encodes a tumour suppressor protein associated with a distinct subnuclear domain, the nuclear body. Various functions have been attributed to the PML nuclear body, but its main biochemical role is still unclear. Recent findings indicate that PML is essential for the proper formation of the nuclear body and can act as a transcriptional co-factor. Here we summarize the current understanding of the biological functions of PML and the nuclear body, and discuss a role for these intra-nuclear structures in the regulation of transcription. |
| Databáze: | OpenAIRE |
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