Oral administration of guanosine impairs inhibitory avoidance performance in rats and mice
| Autor: | Diogo R. Lara, Elsa Regina do Canto Vinade, André Schmidt, Ivan Izquierdo, Diogo O. Souza |
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| Rok vydání: | 2003 |
| Předmět: |
Male
Cognitive Neuroscience Guanosine Administration Oral Experimental and Cognitive Psychology Pharmacology Adenosine receptor antagonist Receptors N-Methyl-D-Aspartate Behavioral Neuroscience Glutamatergic chemistry.chemical_compound Mice medicine Avoidance Learning Animals Receptors AMPA Rats Wistar Neurotransmitter Maze Learning Behavior Animal Purinergic receptor Adenosine Rats Inhibition Psychological chemistry Caffeine Nucleoside Neuroscience medicine.drug |
| Zdroj: | Neurobiology of learning and memory. 81(2) |
| ISSN: | 1074-7427 |
| Popis: | Extracellular guanine-based purines, mainly the nucleoside guanosine, have recently been shown to exert neuroprotective effects, which seem to be related to antagonism of the glutamatergic system. In this study, we investigated the effects of acute oral administration of guanosine on inhibitory avoidance task in rats and mice. We also studied its effects on locomotor activity, anxiety-related behaviors and mechanisms of action involving the purinergic system. Guanosine (2.0 and 7.5mg/kg, per os), administered 75min pretraining, dose-dependently impaired retention of the inhibitory avoidance task in rats and mice, an effect not prevented by the adenosine receptor antagonist caffeine. Guanosine presented no effects on locomotor activity and anxiety-related behaviors. This amnesic effect of guanosine may be compatible with inhibition of glutamatergic system and seems to be not mediated by adenosine. |
| Databáze: | OpenAIRE |
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