Phenotypic markers and BCL-1 gene rearrangements in B-cell chronic lymphocytic leukemia: a Cancer and Leukemia Group B study
Autor: | FE Millard, Bercedis Peterson, Heli Collins, VL Brunetto, C Brabyn, Ivor Royston, R B Weiss, FR Davey, DB Duggan, RA Newman |
---|---|
Rok vydání: | 1993 |
Předmět: |
Adult
Male Chronic lymphocytic leukemia Immunology CD11c CD38 Biology Biochemistry Antigens CD immune system diseases Proto-Oncogene Proteins Acute lymphocytic leukemia White blood cell hemic and lymphatic diseases medicine Humans Cyclin D1 Gene Rearrangement B-Lymphocyte Aged Aged 80 and over CD11 Antigens Receptors IgE Receptors Interleukin-2 hemic and immune systems Gene rearrangement Cell Biology Hematology Middle Aged medicine.disease Leukemia Lymphocytic Chronic B-Cell Leukemia medicine.anatomical_structure Antigens Surface Female CD5 |
Zdroj: | Blood. 82:1239-1246 |
ISSN: | 1528-0020 0006-4971 |
Popis: | The markers, CD11b, CD11c, CD14, CD21, CD23, CD25, CD38, and FMC7 were correlated with morphologic and other laboratory and clinical characteristics of 127 patients with untreated CD5+ chronic lymphocytic leukemia (CLL). Only CD38 and CD21 were significantly associated with atypical CLL morphology. The integrin associated markers CD11b and CD11c were associated with lower leukocyte count (white blood cell count [WBC]) and lower Rai stage. By contrast, the activation antigen CD23 was associated with a higher WBC, higher Rai stage, younger age group, and the presence of lymphadenopathy. Therefore, we conclude that CD23 positivity may reflect a more aggressive form of CLL, and CD11b and CD11c positivity a less aggressive form. The BCL-1 gene rearrangement was present in 5 of 84 (6%) CLL cases examined and was associated with atypical morphology and surface expression of CD11b. Patients with a BCL-1 gene rearrangement may represent a CLL subset or possibly a different B-cell disease. |
Databáze: | OpenAIRE |
Externí odkaz: |