Therapeutic Effects of Anthocyanins for Vision and Eye Health
| Autor: | Hitoshi Matsumoto, Keiko Iwasaki-Kurashige, Yuri Nomi |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
medicine.medical_specialty
genetic structures Pharmaceutical Science Glaucoma Biological Availability Dark Adaptation Review Eye anthocyanin Analytical Chemistry lcsh:QD241-441 Anthocyanins 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine lcsh:Organic chemistry Ophthalmology Normal tension glaucoma Drug Discovery Eye health medicine blood circulation Animals Tissue Distribution myopia Physical and Theoretical Chemistry Vision Ocular 030304 developmental biology 0303 health sciences biology business.industry Regeneration (biology) Organic Chemistry Therapeutic effect ciliary muscle Retinal medicine.disease eye diseases Ciliary muscle glaucoma chemistry Chemistry (miscellaneous) Rhodopsin 030220 oncology & carcinogenesis biology.protein Molecular Medicine sense organs business |
| Zdroj: | Molecules Molecules, Vol 24, Iss 18, p 3311 (2019) |
| ISSN: | 1420-3049 |
| Popis: | Anthocyanin (AC) is widely used as supplement of eye health in Europe and in East Asia. In this review, I describe AC effects to clarify the mechanism is important in order to understand the effects of AC on vision health. The bioavailability of AC is quite low but, reported as intact form and many kinds of metabolite. And AC passes through the blood-aqueous fluid barrier and blood-retinal barrier. In vitro study, AC had a relaxing effect on ciliary muscle which is important to treat both myopia and glaucoma. And AC stimulate the regeneration of rhodopsin in frog rod outer segment. Furthermore, AC could inhibit the axial length and ocular length elongation in a negative lens-induced chick myopia model. In addition, we summarized clinical studies of AC intake improved dark adaptation and transient myopic shift and the improvement on retinal blood circulation in normal tension glaucoma patients. |
| Databáze: | OpenAIRE |
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