Methicillin-Resistant Staphylococcus aureus (MRSA)-Active Metabolites from Platanus occidentalis (American Sycamore)
| Autor: | Amanda Gross, Shabana I. Khan, Mohamed Ibrahim, Melissa R. Jacob, Arsala Mansoor, M. Khalid Ashfaq, Mark T. Hamann |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Methicillin-Resistant Staphylococcus aureus
Micrococcaceae Stereochemistry Flavonoid Pharmaceutical Science Microbial Sensitivity Tests Pharmacognosy medicine.disease_cause Article Analytical Chemistry Trees chemistry.chemical_compound Mississippi Drug Discovery medicine Glycosides Kaempferols Antibacterial agent Pharmacology chemistry.chemical_classification biology Traditional medicine Molecular Structure Organic Chemistry Glycoside Stereoisomerism biology.organism_classification Anti-Bacterial Agents Platanus occidentalis Complementary and alternative medicine chemistry Staphylococcus aureus Molecular Medicine Methicillin Resistance Kaempferol |
| Popis: | One known and three new potent, selective, and nontoxic anti-MRSA metabolites, kaempferol 3-O-alpha-l-(2'',3''-di-E-p-coumaroyl)rhamnoside (1) (IC(50) 2.0 microg/mL), kaempferol 3-O-alpha-l-(2''-E-p-coumaroyl-3''-Z-p-coumaroyl)rhamnoside (2) (IC(50) 0.8 microg/mL), kaempferol 3-O-alpha-l-(2''-Z-p-coumaroyl-3''-E-p-coumaroyl)rhamnoside (3) (IC(50) 0.7 microg/mL), and kaempferol 3-O-alpha-l-(2'',3''-di-Z-p-coumaroyl)rhamnoside (4) (IC(50) 0.4 microg/mL), were isolated from the leaves of the common American sycamore, Platanus occidentalis. Compounds 2-4 are new. Due to the unusual selectivity, potency, and safety of the pure compounds and the semipure glycoside mixture against MRSA, it is clear that this represents a viable class of inhibitors to prevent growth of MRSA on surfaces and systemically. |
| Databáze: | OpenAIRE |
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