Palladium-Catalyzed Ligand-Free Double Cyclization Reactions for the Synthesis of 3-(1′-Indolyl)-phthalides
| Autor: | Bin Yu, Shuo Yuan, Jing-Ya Zhang, Dan-Qing Zhang, Hong-Min Liu |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Indole test
010405 organic chemistry Ligand Chemistry Bioactive molecules Organic Chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences Biochemistry Combinatorial chemistry 0104 chemical sciences Catalysis Phthalide chemistry.chemical_compound Yield (chemistry) Physical and Theoretical Chemistry Palladium Biological evaluation |
| Zdroj: | Organic Letters. 22:814-817 |
| ISSN: | 1523-7052 1523-7060 |
| Popis: | Indole and phthalide are privileged heterocyclic scaffolds in numerous natural products and bioactive molecules. The synthesis and biological evaluation of the compounds combining these two scaffolds have rarely been reported. Herein, we repot the first palladium-catalyzed ligand-free double cyclization reactions that enable efficient synthesis of 3-(1'-indolyl)-phthalides (42 examples, up to 96% yield) under mild conditions. Notably, only 1.0 mol % of catalyst loading is used, suggesting high efficiency. Late-stage elaborations give highly functionalized analogues. |
| Databáze: | OpenAIRE |
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