Quantitative evaluation of sensory irritating and neurobehavioural properties of aliphatic ketones in mice
| Autor: | J.C. Micillino, J. Muller, B. Marignac, J. de Ceaurriz, J.P. Guenier, P. Bonnet |
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| Rok vydání: | 1984 |
| Předmět: |
Male
Atmosphere Exposure Chambers Ketone Respiratory System Toxicology medicine.disease_cause chemistry.chemical_compound Mice Mesityl oxide Helplessness Learned parasitic diseases Acetone medicine Organic chemistry Animals Humans Swimming Isophorone chemistry.chemical_classification Behavior Animal Dose-Response Relationship Drug General Medicine Ketones Methyl isobutyl ketone chemistry Toxicity Irritants lipids (amino acids peptides and proteins) Gases Irritation Aliphatic compound Food Science |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 22(7) |
| ISSN: | 0278-6915 |
| Popis: | A decrease in respiratory rate resulting from irritation of upper airways and a decrease in duration of immobility in a 'behavioural despair' swimming test occurred in mice during and following short-term inhalation exposures to some commonly used aliphatic ketones. Linear concentration-effect relationships were obtained that allowed two different median active levels (MALs) to be calculated. MALs that produced a 50% decrease in respiratory rate (RD50) were calculated as indicators of the sensory irritation potency of diisobutyl ketone, mesityl oxide, methyl amyl ketone, methyl isoamyl ketone and methyl propyl ketone. MALs that produced a 50% decrease in immobility (ID50) were determined for acetone, isophorone, mesityl oxide, methyl amyl ketone, methyl isoamyl ketone, methyl isobutyl ketone and methyl propyl ketone. The systematic determination of MALs permits classification of ketones in terms of their relative potencies for eliciting a given effect. The lowest MAL indicates the primary manifestation of toxicity, against which protection should be taken. MALs associated with such critical responses may be useful in the establishment of safe levels of occupational exposure to ketones, a conclusion supported by the linear relationship that was found to exist between MALs and occupational standards. |
| Databáze: | OpenAIRE |
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