Urinary Cell-Free DNA: Potential and Applications
| Autor: | Valentina Casadio, Samanta Salvi |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Fetal urinary cell-free DNA Urinary cell-free DNA DNA Copy Number Variations Urinary system Prenatal diagnosis Urine Bioinformatics Polymerase Chain Reaction 03 medical and health sciences 0302 clinical medicine Pregnancy Neoplasms Prenatal Diagnosis Animals Humans Medicine Sampling (medicine) Urine Specimen Collection Cancer monitoring Cancer diagnosis Cell-Free Nucleic Acids Female Mutation Prognosis business.industry Cancer Genomic signature medicine.disease 030104 developmental biology Cell-free fetal DNA 030220 oncology & carcinogenesis Personalized medicine business Treatment monitoring |
| Zdroj: | Cell-free DNA as Diagnostic Markers ISBN: 9781493989720 |
| DOI: | 10.1007/978-1-4939-8973-7_15 |
| Popis: | Urine could be a convenient source of biomarkers for different diseases and clinical applications, mostly for cancer diagnosis, prognosis, treatment monitoring, and prenatal diagnosis. The ultra-noninvasive sampling and the possibility to analyze large volume are the main undisputed advantages of urine-based protocols. Recent and comprehensive studies showed that urinary cell-free DNA (ucfDNA) is informative to identify the genomic signature of patients, resulting in a huge tool to track the tumor evolution and for personalized medicine in urological and non-urological cancer.In this chapter, we reported the main published evidences on ucfDNA, with the aim at discussing its promising and translatable role in clinical practices. |
| Databáze: | OpenAIRE |
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