BAT in the Diagnosis of Drug Allergy: a Novel Tool in Clinical Daily Practice?
| Autor: | Jorge Kalil, Mariana Castells, Pedro Giavina-Bianchi, Lucila de Sousa Campos, Violeta Régnier Galvão |
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| Rok vydání: | 2019 |
| Předmět: |
Pulmonary and Respiratory Medicine
Drug Hypersensitivity Immediate medicine.medical_specialty Allergy media_common.quotation_subject Immunology Drug allergy Basophil Degranulation Test beta-Lactams Drug Hypersensitivity Daily practice Immunology and Allergy Medicine Humans Drug reaction Pyrazolones Intensive care medicine media_common business.industry Platinum compounds Anti-Inflammatory Agents Non-Steroidal medicine.disease Basophils Basophil activation Neuromuscular Agents business Neuromuscular Blockers |
| Zdroj: | Current allergy and asthma reports. 19(4) |
| ISSN: | 1534-6315 |
| Popis: | The aim of this study is to critically review the relevant literature published on basophil activation test, presenting the current knowledge and future perspectives. Basophil activation test (BAT) results varied accordingly to the class of the drug studied, and have promising results in immediate hypersensitivity reactions to pyrazolone (selective reactors), neuromuscular blockers, beta-lactams, and platinum compounds, all examples of classical IgE-mediated hypersensitivity drug reactions. Currently, BAT is applied in research settings, but based in the results of our review, the test can be considered as a diagnostic tool for daily practice for selected patients and selected drugs, when the test is available, particularly for patients who experienced severe reactions and when diagnosis cannot be stablished by serum-specific IgE and skin testing, in order to avoid unnecessary drug provocations tests. |
| Databáze: | OpenAIRE |
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