Cysteine Prevents the Development of Experimental Diabetes Induced by Zinc-Binding Substances
| Autor: | G.T. Kartbayeva, A. Zh. Shaybek, K.-D. Kohnert, G. M. Tykezhanova, G.G. Meyramov, Zh. Zh. Zhumagalieva, A. E. Starikova, D. A. Meyramova, O. L. Kovalenko |
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| Rok vydání: | 2020 |
| Předmět: |
Blood Glucose
0301 basic medicine Zinc binding chemistry.chemical_element Zinc General Biochemistry Genetics and Molecular Biology Diabetes Mellitus Experimental Islets of Langerhans 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Insulin-Secreting Cells Animals Molecule Chelation Cysteine General Medicine Sulfur 030104 developmental biology chemistry Cytoprotection Dithizone Biophysics Rabbits 030217 neurology & neurosurgery Experimental diabetes |
| Zdroj: | Bulletin of Experimental Biology and Medicine. 168:621-626 |
| ISSN: | 1573-8221 0007-4888 |
| DOI: | 10.1007/s10517-020-04765-1 |
| Popis: | In experimental rabbits, cysteine injected intravenously in a dose of 1000 mg/kg temporarily bound zinc in β cells and prevented the formation of chelate zinc complexes in response to subsequent injection of diabetogenic zinc-binding substances that induce cell destruction. Injection of cysteine to animals was associated with a sharply negative reaction to zinc in β cells, which attests to blockade of zinc ions. Injection of cysteine few minutes after dithizone and formation of zinc-dithizone complex was followed by displacement of dithizone from the complex and prevented the development of diabetes in most animals. The most plausible mechanism of preventive effect of cysteine is the formation of 2:1 zinc-cysteine complex in β cells with possible fixation of Zn atom between sulfur atoms from SH groups of two cysteine molecules. |
| Databáze: | OpenAIRE |
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