Immunofluorescence as a diagnostic aid in cryptococcal meningitis
| Autor: | Paul H. Jacobs, Betty Russell, Paul L. Wolf |
|---|---|
| Rok vydání: | 1974 |
| Předmět: |
Pathology
medicine.medical_specialty Cryptococcus Fluorescent Antibody Technique Immunofluorescence Pathology and Forensic Medicine Serology Antigen Prednisone medicine Diabetes Mellitus Methods Humans Meningitis Direct fluorescent antibody Cryptococcus neoformans medicine.diagnostic_test Chlorambucil biology business.industry General Medicine Cryptococcosis Middle Aged medicine.disease biology.organism_classification Immunodiffusion Rheumatoid arthritis Immunology biology.protein Female Antibody business medicine.drug |
| Zdroj: | Human pathology. 5(6) |
| ISSN: | 0046-8177 |
| Popis: | To the Editor.— Crytpococcosis involves the lungs and the central nervous system. The causative organism,Cryptococcus neoformans, is frequently an opportunistic, secondary invader, associated with severe debilitating illness and drug treatments. The diagnosis depends on culture procedures and biochemical techniques performed on the positive cultures, as well as serological tests, tube agglutination, complement-fixation, immunodiffusion, and latex cryptococcal antigen agglutination tests.1-3 A patient with long-standing rheumatoid arthritis had received prednisone and chlorambucil and developed steroid-induced diabetes mellitus and subsequentCryptococcusmeningitis, which caused her death. A new rapid method utilizing indirect immunofluorescence to identify cryptococcal antigen and antibody in body fluids is described here. Report of a Case.— A 61-year-old white woman with a long history of rheumatoid arthritis since age 14 had been treated with prednisone and for a short period with chlorambucil. Adult onset diabetes mellitus developed that was probably steroid induced. Chlorambucil therapy was begun in early |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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