Ethylene, an early marker of systemic inflammation in humans
| Autor: | Simona M. Cristescu, Geert van den Bogaart, Frans J. M. Harren, Terence H. Risby, Laurent M. Paardekooper, Nandor Marczin, Matthijs Kox, Peter Pickkers, Maura B. Bendix, Anne H. Neerincx, Ilse Dingjan, Martin ter Beest |
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| Přispěvatelé: | Molecular Immunology |
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
MECHANISM Lipopolysaccharides Male Lipopolysaccharide Cancer development and immune defence Radboud Institute for Molecular Life Sciences [Radboudumc 2] lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] Pharmacology Systemic inflammation 01 natural sciences Lipid peroxidation chemistry.chemical_compound LASER PHOTOACOUSTIC DETECTION Leukocytes IMMUNE-RESPONSE IN-VIVO Respiratory Burst Multidisciplinary LIPID-PEROXIDATION Healthy Volunteers 3. Good health Respiratory burst Multidisciplinary Sciences Breath Tests Science & Technology - Other Topics Medicine Cytokines Molecular and Laser Physics medicine.symptom Adult Science OXIDASE DENDRITIC CELLS Article Proinflammatory cytokine 010309 optics 03 medical and health sciences Young Adult Immune system In vivo 0103 physical sciences medicine Humans PLANTS Inflammation Science & Technology CROSS-PRESENTATION business.industry Ethylenes 030104 developmental biology chemistry Immunology HUMAN SKIN Lipid Peroxidation business Biomarkers Hormone |
| Zdroj: | Scientific Reports Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017) Scientific Reports, 7:6889. Nature Publishing Group Scientific Reports, 7 |
| ISSN: | 2045-2322 |
| Popis: | Ethylene is a major plant hormone mediating developmental processes and stress responses to stimuli such as infection. We show here that ethylene is also produced during systemic inflammation in humans and is released in exhaled breath. Traces of ethylene were detected by laser spectroscopy both in vitro in isolated blood leukocytes exposed to bacterial lipopolysaccharide (LPS) as well as in vivo following LPS administration in healthy volunteers. Exposure to LPS triggers formation of ethylene as a product of lipid peroxidation induced by the respiratory burst. In humans, ethylene was detected prior to the increase of blood levels of inflammatory cytokines and stress-related hormones. Our results highlight that ethylene release is an early and integral component of in vivo lipid peroxidation with important clinical implications as a breath biomarker of bacterial infection. |
| Databáze: | OpenAIRE |
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